Generation of phosphorylated histone H2AX by benzene metabolites.

Abstract

Benzene is a well known environmental carcinogen which causes myeloid leukemia. DNA damage induced by benzene metabolites such as hydroquinone (HQ) and p-benzoquinone (BQ) is one reason for the leukemogenesis. In this study, we showed that treatment with HQ and BQ quickly and clearly generated phosphorylated histone H2AX (gamma-H2AX) which has been recently… (More)
DOI: 10.1016/j.tiv.2008.09.005

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