Generation of patterns from gene expression data by assigning confidence to differentially expressed genes

@article{Manduchi2000GenerationOP,
  title={Generation of patterns from gene expression data by assigning confidence to differentially expressed genes},
  author={Elisabetta Manduchi and Gregory R. Grant and Steven E. McKenzie and G. Christian Overton and Saul Surrey and Christian J. Stoeckert},
  journal={Bioinformatics},
  year={2000},
  volume={16 8},
  pages={685-98}
}
MOTIVATION A protocol is described to attach expression patterns to genes represented in a collection of hybridization array experiments. Discrete values are used to provide an easily interpretable description of differential expression. Binning cutoffs for each sample type are chosen automatically, depending on the desired false-positive rate for the predictions of differential expression. Confidence levels are derived for the statement that changes in observed levels represent true changes in… CONTINUE READING