Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells.

@article{Chandra2009GenerationOP,
  title={Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells.},
  author={Vikash Chandra and G Swetha and Smruti Madan Phadnis and Prabha Damodaran Nair and Ramesh Bhonde},
  journal={Stem cells},
  year={2009},
  volume={27 8},
  pages={
          1941-53
        }
}
The success of cell replacement therapy for diabetes depends on the availability and generation of an adequate number of islets, preferably from an autologous origin. Stem cells are now being probed for the generation of physiologically competent, insulin-producing cells. In this investigation, we explored the potential of adipose tissue-derived stem cells (ASCs) to differentiate into pancreatic hormone-expressing islet-like cell aggregates (ICAs). We initiated ASC culture from epididymal fat… CONTINUE READING
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