Generation of new Notch2 mutant alleles.

@article{Mccright2006GenerationON,
  title={Generation of new Notch2 mutant alleles.},
  author={Brent Mccright and Julie Lozier and Thomas Gridley},
  journal={Genesis},
  year={2006},
  volume={44 1},
  pages={29-33}
}
The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism, and mutations in its components disrupt embryonic development in many organisms and cause inherited diseases in humans. We previously described construction and analysis of a hypomorphic allele of the Notch2 gene. Homozygosity for this allele leads to embryonic and perinatal lethality due to cardiovascular and kidney defects. We report here novel Notch2 mutant alleles generated by gene targeting in… CONTINUE READING

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