Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.

@article{Reynolds1992GenerationON,
  title={Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.},
  author={B. Reynolds and S. Weiss},
  journal={Science},
  year={1992},
  volume={255 5052},
  pages={
          1707-10
        }
}
Neurogenesis in the mammalian central nervous system is believed to end in the period just after birth; in the mouse striatum no new neurons are produced after the first few days after birth. In this study, cells isolated from the striatum of the adult mouse brain were induced to proliferate in vitro by epidermal growth factor. The proliferating cells initially expressed nestin, an intermediate filament found in neuroepithelial stem cells, and subsequently developed the morphology and antigenic… Expand
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