Generation of neuronal progenitor cells in response to tumors in the human brain.

@article{Macas2014GenerationON,
  title={Generation of neuronal progenitor cells in response to tumors in the human brain.},
  author={Jadranka Macas and Min-Chi Ku and Christian Nern and Yuanzhi Xu and Helmut Buehler and Marc Remke and M Synowitz and Kea Franz and Volker Seifert and Karl Heinz Plate and Helmut Kettenmann and Rainer Glass and Stefan Momma},
  journal={Stem cells},
  year={2014},
  volume={32 1},
  pages={244-57}
}
Data from transgenic mouse models show that neuronal progenitor cells (NPCs) migrate toward experimental brain tumors and modulate the course of pathology. However, the pathways whereby NPCs are attracted to CNS neoplasms are not fully understood and it is unexplored if NPCs migrate toward brain tumors (high-grade astrocytomas) in humans. We analyzed the tumor-parenchyma interface of neurosurgical resections for the presence of (NPCs) and distinguished these physiological cells from the tumor… CONTINUE READING
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