Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization.

@article{Rowland2011GenerationON,
  title={Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization.},
  author={James W Rowland and Jason J Lee and Ryan P F Salewski and Eftekhar Eftekharpour and Derek van der Kooy and Michael G. Fehlings},
  journal={Stem cells and development},
  year={2011},
  volume={20 11},
  pages={1829-45}
}
Neural stem cell-based approaches to repair damaged white matter in the central nervous system have shown great promise; however, the optimal cell population to employ in these therapies remains undetermined. A default mechanism of neural induction may function during development, and in embryonic stem cells (ESCs) neural differentiation is elicited in the absence of any extrinsic signaling in minimal, serum-free culture conditions. The default mechanism can be used to derive clonal neurosphere… CONTINUE READING

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will become nerve cells unless told otherwise

  • D Kamiya, S Banno, +6 authors H Kiyonari
  • 2011

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