Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts.

  title={Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts.},
  author={Riguo Fang and Kang Liu and Yang Zhao and Haibo Li and Dicong Zhu and Yuanyuan Du and Chengang Xiang and Xiang Li and Haisong Liu and Zhenchuan Miao and Xing Zhang and Yan Shi and Weifeng Yang and Jun Xu and Hongkui Deng},
  journal={Cell stem cell},
  volume={15 4},
Conventional embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) derived from primates resemble mouse epiblast stem cells, raising an intriguing question regarding whether the naive pluripotent state resembling mouse embryonic stem cells (mESCs) exists in primates and how to capture it in vitro. Here we identified several specific signaling modulators that are sufficient to generate rhesus monkey fibroblast-derived iPSCs with the features of naive pluripotency in terms of… CONTINUE READING

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