Generation of multiple replication-competent retroviruses through recombination between PreXMRV-1 and PreXMRV-2.

@article{DelviksFrankenberry2013GenerationOM,
  title={Generation of multiple replication-competent retroviruses through recombination between PreXMRV-1 and PreXMRV-2.},
  author={Krista A Delviks-Frankenberry and Tobias Paprotka and Oya Cing{\"o}z and Sheryl J. Wildt and Weipeng Hu and John M Coffin and Vinay K Pathak},
  journal={Journal of virology},
  year={2013},
  volume={87 21},
  pages={
          11525-37
        }
}
We previously identified two novel endogenous murine leukemia virus proviruses, PreXMRV-1 and PreXMRV-2, and showed that they most likely recombined during xenograft passaging of a human prostate tumor in mice to generate xenotropic murine leukemia virus-related virus (XMRV). To determine the recombination potential of PreXMRV-1 and PreXMRV-2, we examined the generation of replication-competent retroviruses (RCRs) over time in a cell culture system. We observed that either virus alone was… CONTINUE READING
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