Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells.

Abstract

Despite therapeutic advancement, pulmonary disease still remains a major cause of morbidity and mortality around the world. Opportunities to study human lung disease either in vivo or in vitro are currently limited. Using induced pluripotent stem cells (iPSCs), we generated mature multiciliated cells in a functional airway epithelium. Robust… (More)
DOI: 10.1073/pnas.1403470111

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Cite this paper

@article{Firth2014GenerationOM, title={Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells.}, author={Amy Leanne Firth and Carl T. Dargitz and Susan J. Qualls and Tushar Menon and Rebecca Wright and Oded Singer and Fred H. Gage and A. S. Khanna and Inder M Verma}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2014}, volume={111 17}, pages={E1723-30} }