Generation of motor neurons by coculture of retinoic acid-pretreated embryonic stem cells with chicken notochords.

@article{Anjomshoa2009GenerationOM,
  title={Generation of motor neurons by coculture of retinoic acid-pretreated embryonic stem cells with chicken notochords.},
  author={Maryam Anjomshoa and Khadijeh Karbalaie and M. N. Mardani and Shahnaz Razavi Razavi and Somayeh Tanhaei and Mohammad Hossein Nasr-esfahani and Hossein Baharvand},
  journal={Stem cells and development},
  year={2009},
  volume={18 2},
  pages={
          259-67
        }
}
Understanding neuroectoderm formation and its subsequent diversification to functional neural subtypes remains elusive. We have shown here for the first time that embryonic stem cells (ESCs) can differentiate into neurons and motor neurons (MNs) by using a coculture embryonic notochord model in vitro. Mouse ESCs were induced to form neural precursors via timed exposure to retinoic acid (RA) using the 4-/4+ RA protocol. These cells were then cocultured with alginate bead-encapsulated notochords… CONTINUE READING
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Neuronal induction and regional identity by co-culture of adherent human embryonic stem cells with chicken notochords and somites.

  • The International journal of developmental biology
  • 2011
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