Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth.

@article{Matsuda2011GenerationOM,
  title={Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth.},
  author={Atsushi Matsuda and Masahiro Ogawa and Hideyuki Yanai and Daiji Naka and Ayana Goto and Tomoka Ao and Yuji Tanno and Kiyoshi Takeda and Yoshinori Watanabe and Kenya Honda and T. Taniguchi},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={411 1},
  pages={7-13}
}
The activation of innate immune responses is critical to host defense against microbial infections, wherein nucleic acid-sensing pattern recognition receptors recognize DNA or RNA from viruses or bacteria and activate downstream signaling pathways. In a search for new DNA-sensing molecules that regulate innate immune responses, we identified RNA-binding motif protein 3 (RBM3), whose role has been implicated in the regulation of cell growth. In this study, we generated Rbm3-deficient (Rbm3… CONTINUE READING