Generation of mice deficient for Lbx2, a gene expressed in the urogenital system, nervous system, and Pax3 dependent tissues.

@article{Wei2007GenerationOM,
  title={Generation of mice deficient for Lbx2, a gene expressed in the urogenital system, nervous system, and Pax3 dependent tissues.},
  author={Ke Min Wei and Jiyuan Chen and Kevan M. Akrami and Rashmi Sekhon and Fabian Chen},
  journal={Genesis},
  year={2007},
  volume={45 6},
  pages={
          361-8
        }
}
Lbx2 is a member of the ladybird family of homeobox genes. The first murine ortholog identified, Lbx1, is required for hypaxial musculature and dorsal spinal cord neuron development. The second murine ortholog, Lbx2, is expressed in the developing urogenital and nervous systems. To elucidate the function of Lbx2, we generated a gene-targeted allele of Lbx2 in mice. Lbx2 deficiency did not impair mouse development, and Lbx2 null mice appeared healthy and fertile. Replacement of Lbx2 by the lacZ… CONTINUE READING