Generation of metastatic variants of Eker renal carcinoma cell lines for experimental investigation of renal cancer metastasis.

Abstract

We and others have demonstrated that a mutation in Tsc2 is the rate-limiting step for renal carcinogenesis in the Eker rat model. Although inactivation of Tsc2 results in development of renal tumors, it is not sufficient for metastatic renal cell carcinomas (RCs) in the Eker rat. To investigate the additional genetic event(s) necessary for cancer metastasis… (More)

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Cite this paper

@article{Fukuda1998GenerationOM, title={Generation of metastatic variants of Eker renal carcinoma cell lines for experimental investigation of renal cancer metastasis.}, author={T. Fukuda and Y. Hirayama and Hidetsugu Mitani and H. Maeda and M. Tsutsumi and Y. Konishi and Okio Hino}, journal={Japanese journal of cancer research : Gann}, year={1998}, volume={89 11}, pages={1104-8} }