Generation of mature fat pads in vitro and in vivo utilizing 3-D long-term culture of 3T3-L1 preadipocytes.

@article{Fischbach2004GenerationOM,
  title={Generation of mature fat pads in vitro and in vivo utilizing 3-D long-term culture of 3T3-L1 preadipocytes.},
  author={Claudia Fischbach and Thilo Spruss and Barbara Weiser and Markus Neubauer and Christian Becker and Michael C Hacker and Achim Prof. Dr. G{\"o}pferich and Torsten Blunk},
  journal={Experimental cell research},
  year={2004},
  volume={300 1},
  pages={
          54-64
        }
}
Tissue-inherent factors such as cell-cell and cell-extracellular matrix interactions are regarded to exert a potentially large impact on adipogenesis as well as on secretory functions of adipose tissue. However, an appropriate 3-D adipogenesis model useful for addressing such interactions is still lacking. In this study, using tissue-engineering techniques, we demonstrate for the first time the development of coherent fat pads consisting of unilocular signet-ring cells in vitro. The constructs… CONTINUE READING
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