Generation of kidney organoids from human pluripotent stem cells

@article{Takasato2016GenerationOK,
  title={Generation of kidney organoids from human pluripotent stem cells},
  author={Minoru Takasato and Pei X. Er and Han Sheng Chiu and Melissa H Little},
  journal={Nature Protocols},
  year={2016},
  volume={11},
  pages={1681-1692}
}
The human kidney develops from four progenitor populations—nephron progenitors, ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors—resulting in the formation of maximally 2 million nephrons. Until recently, the reported methods differentiated human pluripotent stem cells (hPSCs) into either nephron progenitor or ureteric epithelial progenitor cells, consequently forming only nephrons or collecting ducts, respectively. Here we detail a protocol that… CONTINUE READING
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