Generation of integration-free neural progenitor cells from cells in human urine

@article{Wang2013GenerationOI,
  title={Generation of integration-free neural progenitor cells from cells in human urine},
  author={Lihui Wang and Linli Wang and Wenhao Huang and Huanxing Su and Yanting Xue and Zhenghui Su and Baojian Liao and Haitao Wang and Xichen Bao and Dajiang Qin and Jufang He and Wutian Wu and Kwok-fai So and Guangjin Pan and Duanqing Pei},
  journal={Nature Methods},
  year={2013},
  volume={10},
  pages={84-89}
}
Human neural stem cells hold great promise for research and therapy in neural disease. We describe the generation of integration-free and expandable human neural progenitor cells (NPCs). We combined an episomal system to deliver reprogramming factors with a chemically defined culture medium to reprogram epithelial-like cells from human urine into NPCs (hUiNPCs). These transgene-free hUiNPCs can self-renew and can differentiate into multiple functional neuronal subtypes and glial cells in vitro… 

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