Generation of insulin-secreting cells from adult rat pancreatic ductal epithelial cells induced by hepatocyte growth factor and betacellulin-delta4.

@article{Zhan2009GenerationOI,
  title={Generation of insulin-secreting cells from adult rat pancreatic ductal epithelial cells induced by hepatocyte growth factor and betacellulin-delta4.},
  author={Xiao-rong Zhan and Xin-Yu Li and Xiao-min Liu and Jianhua Zhou and Yu-ling Yang and Ran Yi and Jing Zhang and Bao-feng Yang},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={382 2},
  pages={
          375-80
        }
}

• Xiao-rong Zhan, Xin-Yu Li, +5 authors Bao-feng Yang
• Published in
  Biochemical and biophysical research…
  2009
• DOI:10.1016/j.bbrc.2009.03.029

The present study was conducted to identify effective factors that could induce differentiation of pancreatic ductal epithelial cells (PDECs) into insulin-producing cells. We examined the effect of hepatocyte growth factor (HGF) and betacellulin-delta4 (BTC-delta4) on PDECs. We isolated PDECs from adult rats and stimulated them with HGF and BTC-delta4 for 28days. We observed several characteristics of PDECs after induction, including functional changes in PDECs, differentiation rate, and… CONTINUE READING

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