Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine.

@article{Honda2010GenerationOI,
  title={Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine.},
  author={Arata Honda and Michiko Hirose and Masanori Hatori and Shogo Matoba and Hiroyuki Miyoshi and Kimiko Inoue and Atsuo Ogura},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 41},
  pages={31362-9}
}
Human induced pluripotent stem (iPS) cells have the potential to establish a new field of promising regenerative medicine. Therefore, the safety and the efficiency of iPS-derived cells must be tested rigorously using appropriate animal models before human trials can commence. Here, we report the establishment of rabbit iPS cells as the first human-type iPS cells generated from a small laboratory animal species. Using lentiviral vectors, four human reprogramming genes (c-MYC, KLF4, SOX2, and… CONTINUE READING
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