Generation of incednine derivatives by mutasynthesis

  title={Generation of incednine derivatives by mutasynthesis},
  author={Akimasa Miyanaga and Ryoma Takaku and Makoto Takaishi and Etsu Tashiro and Fumitaka Kudo and Tadashi Eguchi},
  journal={The Journal of Antibiotics},
The macrolactam antibiotic incednine, isolated from Streptomyces sp. ML694–90F3, contains a ( S )-3-aminobutyric acid moiety in its polyketide aglycon. In this study, we performed mutasynthesis to generate incednine derivatives. We successfully obtained 28-methylincednine by feeding 3-aminopentanoic acid into culture of a strain in which the glutamate 2,3-aminomutase gene idnL4 , whose product is responsible for supplying 3-aminobutyric acid, was disrupted. 28-Methylincednine showed similar… 


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