Generation of in silico predicted coxsackievirus B3-derived MHC class I epitopes by proteasomes

@article{Voigt2009GenerationOI,
  title={Generation of in silico predicted coxsackievirus B3-derived MHC class I epitopes by proteasomes},
  author={Antje Voigt and Sandra J{\"a}kel and Kathrin Textoris-Taube and Christin Keller and Ilse Drung and Gudrun Szalay and Karin Klingel and Petra Henklein and Karl Stangl and Peter Michael Kloetzel and Ulrike Kuckelkorn},
  journal={Amino Acids},
  year={2009},
  volume={39},
  pages={243-255}
}
Proteasomes are known to be the main suppliers of MHC class I (MHC-I) ligands. In an attempt to identify coxsackievirus B3 (CVB3)-MHC-I epitopes, a combined approach of in silico MHC-I/transporters associated with antigen processing (TAP)-binding and proteasomal cleavage prediction was applied. Accordingly, 13 potential epitopes originating from the structural and non-structural protein region of CVB3 were selected for further in vitro processing analysis by proteasomes. Mass spectrometry… CONTINUE READING

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