Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules

@article{Li2011GenerationOI,
  title={Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules},
  author={Yanqin Li and Qiang Zhang and Xiaolei Yin and Weifeng Yang and Yuanyuan Du and Pingping Hou and Jian Ping Ge and Chun Liu and Weiqi Zhang and Xu Sunny Zhang and Yetao Wu and Honggang Li and Kang Liu and Chen Wu and Zhihua Song and Yang Zhao and Yan Shi and Hongkui Deng},
  journal={Cell Research},
  year={2011},
  volume={21},
  pages={196-204}
}
The introduction of four transcription factors Oct4, Klf4, Sox2 and c-Myc by viral transduction can induce reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), but the use of iPSCs is hindered by the use of viral delivery systems. Chemical-induced reprogramming offers a novel approach to generating iPSCs without any viral vector-based genetic modification. Previous reports showed that several small molecules could replace some of the reprogramming factors although at… CONTINUE READING
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