Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride.

@article{Wilson2009GenerationOH,
  title={Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride.},
  author={David M Wilson and Ralph E. Hurd and Kayvan R. Keshari and Mark van Criekinge and Albert P Chen and Sarah J. Nelson and Daniel B. Vigneron and John Kurhanewicz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 14},
  pages={
          5503-7
        }
}
In this manuscript, the remarkable NMR signal enhancement that can be provided by dynamic nuclear polarization (DNP) was combined with the reactivity of acetic anhydride with amines to perform rapid, high SNR analyses of amino acid mixtures and to hyperpolarize new biomolecules of interest. [1,1-(13)C] acetic anhydride is an excellent substrate for DNP hyperpolarization because it can be well polarized in only 30 min and has a relatively long T(1) relaxation time (33.9 s at 11.7 T and 37… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

A new direction for polarized carbon-13 MRI.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.

ACKNOWLEDGEMENTS: Grant sponsors: National Institutes of Health (R21 EB005363, R01 EB007588); NIBIB T32 Training Grant 1 T32 ED001631

Ardenkjaer-Larsen
  • PNAS
  • 2003
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL