Generation of human regulatory gammadelta T cells by TCRgammadelta stimulation in the presence of TGF-beta and their involvement in the pathogenesis of systemic lupus erythematosus.

@article{Li2011GenerationOH,
  title={Generation of human regulatory gammadelta T cells by TCRgammadelta stimulation in the presence of TGF-beta and their involvement in the pathogenesis of systemic lupus erythematosus.},
  author={Xiaoyan Li and Ning Kang and Xuan Zhang and Xiaoying Dong and Wei Wei and Lianxian Cui and Domenico Ba and Wei Song He},
  journal={Journal of immunology},
  year={2011},
  volume={186 12},
  pages={
          6693-700
        }
}
As a component of the innate immune cell population, γδ T cells are involved in tumor immunosurveillance and host defense against viral invasion. In this study, we demonstrated a novel function of human γδ T cells as regulatory cells by detecting their suppressive effect on the proliferation of autologous naive CD4(+) T cells. These regulatory γδ T cells (γδ Tregs) could be generated in vitro by stimulating with anti-TCRγδ in the presence of TGF-β and IL-2. Similar to CD4(+)Foxp3(+) Tregs… CONTINUE READING
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