Generation of human interferon gamma and tumor Necrosis factor alpha chimeric TNT-3 fusion proteins.

@article{Sharifi2002GenerationOH,
  title={Generation of human interferon gamma and tumor Necrosis factor alpha chimeric TNT-3 fusion proteins.},
  author={Jahangir Sharifi and Leslie A Khawli and Peisheng Hu and Jaili Li and Alan L. Epstein},
  journal={Hybridoma and hybridomics},
  year={2002},
  volume={21 6},
  pages={421-32}
}
Studies have shown that cytokines can effectively treat solid tumors by a direct cytotoxic effect as well as by immunomodulation. Both human interferon gamma (IFNgamma) and tumor necrosis factor alpha (TNFalpha) have been used to treat a variety of colon carcinoma cell lines and tumors in patients. These cytokines, however, are dose limited by their toxicity and fast clearance rates when given intravenously. To improve their therapeutic value, we now report on the generation of two new fusion… CONTINUE READING

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