Generation of human inflammation-resistant endothelial progenitor cells by A20 gene transfer.

@article{Liu2010GenerationOH,
  title={Generation of human inflammation-resistant endothelial progenitor cells by A20 gene transfer.},
  author={Jia Wei Liu and Sylvie Dunoyer-Geindre and Marcel Blot-Chabaud and Florence Sabatier and R J Fish and Henri Bounameaux and Françoise Dignat-George and Egbert K. O. Kruithof},
  journal={Journal of vascular research},
  year={2010},
  volume={47 2},
  pages={157-67}
}
Inflammatory activation of the vascular endothelium is a major contributory factor to ischemic cardiovascular disease. Endothelial progenitor cells (EPCs) are being investigated for the treatment of ischemic disease or to coat vein grafts for bypass surgery. As an inflammatory environment might reduce their therapeutic efficacy, we sought to generate EPCs that are less sensitive to inflammatory activation. EPCs were obtained from human umbilical cord blood and transduced with a lentiviral… CONTINUE READING