Generation of human β-thalassemia induced pluripotent stem cells from amniotic fluid cells using a single excisable lentiviral stem cell cassette.

@article{Fan2012GenerationOH,
  title={Generation of human β-thalassemia induced pluripotent stem cells from amniotic fluid cells using a single excisable lentiviral stem cell cassette.},
  author={Yong Fan and Yumei Luo and Xinjie Chen and Qing Li and Xiaofang Sun},
  journal={The Journal of reproduction and development},
  year={2012},
  volume={58 4},
  pages={404-9}
}
Induced pluripotent stem cells (iPSCs) derived from somatic cells of patients represent a powerful tool for biomedical research and may have a wide range of applications in cell and gene therapy. However, the safety issues and the low efficiency associated with generating human iPSCs have limited their usage in clinical settings. The cell type used to… CONTINUE READING