Generation of histo-anatomically representative models of the individual heart: tools and application

  title={Generation of histo-anatomically representative models of the individual heart: tools and application},
  author={Gernot Plank and Rebecca A. B. Burton and Patrick W Hales and Martin J. Bishop and Tahir Mansoori and Miguel O. Bernabeu and Alan Garny and Anton J. Prassl and Christian Bollensdorff and Fleur E. Mason and Fahd Mahmood and Blanca Rodr{\'i}guez and Vicente Grau and J{\"u}rgen E. Schneider and David J. Gavaghan and Peter Kohl},
  journal={Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
  pages={2257 - 2292}
  • G. Plank, Rebecca A. B. Burton, P. Kohl
  • Published 13 June 2009
  • Biology
  • Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
This paper presents methods to build histo-anatomically detailed individualized cardiac models. The models are based on high-resolution three-dimensional anatomical and/or diffusion tensor magnetic resonance images, combined with serial histological sectioning data, and are used to investigate individualized cardiac function. The current state of the art is reviewed, and its limitations are discussed. We assess the challenges associated with the generation of histo-anatomically representative… 

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