Generation of highly specific aptamers via micromagnetic selection.

  title={Generation of highly specific aptamers via micromagnetic selection.},
  author={Seung Soo Oh and Jiangrong Qian and Xinhui Lou and Yanting Zhang and Yi Xiao and Hyongsok Tom Soh},
  journal={Analytical chemistry},
  volume={81 13},
Aptamers are nucleic acid-based reagents that bind to target molecules with high affinity and specificity. However, methods for generating aptamers from random combinatorial libraries (e.g., systematic evolution of ligands by exponential enrichment (SELEX)) are often labor-intensive and time-consuming. Recent studies suggest that microfluidic SELEX (M-SELEX) technology can accelerate aptamer isolation by enabling highly stringent selection conditions through the use of very small amounts of… CONTINUE READING
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