Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus.

  title={Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus.},
  author={O. -T. Beck and Max S. Topp and Ulrike Koehl and Emmanuel Roilides and Maria Simitsopoulou and Mitra Hanisch and Jacqueline Sarfati and Jean Paul Latg{\'e} and Thomas Klingebiel and Hermann Einsele and Thomas Lehrnbecher},
  volume={107 6},
Invasive aspergillosis remains a serious complication in patients undergoing allogeneic stem cell transplantation (SCT). Since it became clear that lymphocytes provide a critical secondary defense against fungi, adoptive transfer of functionally active anti-Aspergillus T cells might be an option to restore adaptive immune effector mechanisms. Using the interferon (IFN)-gamma secretion assay, we isolated human activated T cells upon stimulation with a cellular extract of Aspergillus fumigatus… CONTINUE READING


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