Generation of hepatitis C virus-like particles by use of a recombinant vesicular stomatitis virus vector.

@article{Ezelle2002GenerationOH,
  title={Generation of hepatitis C virus-like particles by use of a recombinant vesicular stomatitis virus vector.},
  author={Heather J. Ezelle and Dubravka Markovi{\'c} and Glen N Barber},
  journal={Journal of virology},
  year={2002},
  volume={76 23},
  pages={
          12325-34
        }
}
Hepatitis C virus (HCV), a major etiologic agent of hepatocellular carcinoma, presently infects approximately 400 million people worldwide, making the development of protective measures against HCV infection a key objective. Here we have generated a recombinant vesicular stomatitis virus (VSV), which expresses the HCV structural proteins, by inserting the contiguous Core, E1, and E2 coding region of HCV into the VSV genome. Recombinant VSV expressing HCV Core, E1, and E2 (VSV-HCV-C/E1/E2) grew… CONTINUE READING
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