Generation of hazardous methyl azide and its application to synthesis of a key-intermediate of picarbutrazox, a new potent pesticide in flow.

@article{Ichinari2017GenerationOH,
  title={Generation of hazardous methyl azide and its application to synthesis of a key-intermediate of picarbutrazox, a new potent pesticide in flow.},
  author={Daisuke Ichinari and Aiichiro Nagaki and Jun-Ichi Yoshida},
  journal={Bioorganic & medicinal chemistry},
  year={2017},
  volume={25 23},
  pages={6224-6228}
}
Generation and reactions of methyl azide (MeN3) were successfully performed by using a flow reactor system, demonstrating that the flow method serves as a safe method for handling hazardous explosive methyl azide. The reaction of NaN3 and Me2SO4 in a flow reactor gave a MeN3 solution, which was used for Huisgen reaction with benzoyl cyanide in a flow… CONTINUE READING