Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells.

@article{Mora2006GenerationOG,
  title={Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells.},
  author={J Rodrigo Mora and Makoto Iwata and Bertus Eksteen and Si-young Song and Tobias Junt and Balimkiz Senman and Kevin L Otipoby and Aya Yokota and Hajime Takeuchi and Paola Ricciardi-Castagnoli and Klaus Rajewsky and David H Adams and Ulrich H von Andrian},
  journal={Science},
  year={2006},
  volume={314 5802},
  pages={
          1157-60
        }
}
Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion… CONTINUE READING

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