Generation of germline-competent induced pluripotent stem cells

@article{Okita2007GenerationOG,
  title={Generation of germline-competent induced pluripotent stem cells},
  author={K. Okita and T. Ichisaka and S. Yamanaka},
  journal={Nature},
  year={2007},
  volume={448},
  pages={313-317}
}
We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and subsequent selection for Fbx15 (also called Fbxo15) expression. These induced pluripotent stem (iPS) cells (hereafter called Fbx15 iPS cells) are similar to embryonic stem (ES) cells in morphology, proliferation and teratoma formation; however, they are different with regards to gene expression and DNA methylation… Expand
The timing of retroviral silencing correlates with the quality of induced pluripotent stem cell lines.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 37 REFERENCES
Retroviral Expression in Embryonic Stem Cells and Hematopoietic Stem Cells
...
1
2
3
4
...