Generation of gene-targeted mice using embryonic stem cells derived from a transgenic mouse model of Alzheimer’s disease


Gene-targeting technology using mouse embryonic stem (ES) cells has become the “gold standard” for analyzing gene functions and producing disease models. Recently, genetically modified mice with multiple mutations have increasingly been produced to study the interaction between proteins and polygenic diseases. However, introduction of an additional mutation… (More)
DOI: 10.1007/s11248-012-9651-x


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