Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.

@article{Shultz2010GenerationOF,
  title={Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.},
  author={Leonard D Shultz and Yoriko Saito and Yuho Najima and Satoshi Tanaka and T. Ochi and Mariko Tomizawa and Takehiko Doi and Akiko Sone and Nahoko Suzuki and Hiroshi Fujiwara and Masaki Yasukawa and Fumihiko Ishikawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 29},
  pages={13022-7}
}
Whereas humanized mouse models have contributed significantly to human immunology research, human T cells developing in mouse thymic environment fail to demonstrate HLA-restricted function. To achieve HLA-restricted human immune response, we created an immune-compromised non-obese diabetic/SCID/IL2rg(null) strain (NSG) with homozygous expression of HLA class I heavy chain and light chain (NSG-HLA-A2/HHD). Transplantation of purified Lin-CD34+CD38- human hematopoietic stem cells into NSG-HLA-A2… CONTINUE READING
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