Generation of formate by the formyltransferase/hydrolase complex (Fhc) from Methylobacterium extorquens AM1

@article{Pomper2002GenerationOF,
  title={Generation of formate by the formyltransferase/hydrolase complex (Fhc) from Methylobacterium extorquens AM1},
  author={B. Pomper and O. Saurel and A. Milon and J. Vorholt},
  journal={FEBS Letters},
  year={2002},
  volume={523}
}
  • B. Pomper, O. Saurel, +1 author J. Vorholt
  • Published 2002
  • Medicine, Biology
  • FEBS Letters
  • Methylobacterium extorquens AM1 possesses a formyltransferase (Ftr) complex that is essential for growth in the presence of methanol and involved in formaldehyde oxidation to CO2. One of the subunits of the complex carries the catalytic site for transfer of the formyl group from tetrahydromethanopterin to methanofuran (MFR). We now found via nuclear magnetic resonance‐based studies that the Ftr complex also catalyzes the hydrolysis of formyl‐MFR and generates formate. The enzyme was therefore… CONTINUE READING

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