Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells.

@article{Isono2014GenerationOF,
  title={Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells.},
  author={Kaori Isono and Hirofumi Jono and Yuki Ohya and Nobuaki Shiraki and Taiji Yamazoe and Ayaka Sugasaki and Takumi Era and Noemi Fusaki and Masayoshi Tasaki and Mitsuharu Ueda and Satoru Shinriki and Yukihiro Inomata and S. Kume and Yukio Ando},
  journal={Stem cell research},
  year={2014},
  volume={12 2},
  pages={574-83}
}
Familial amyloidotic polyneuropathy (FAP) is a hereditary amyloidosis induced by amyloidogenic transthyretin (ATTR). Because most transthyretin (TTR) in serum is synthesized by the liver, liver transplantation (LT) is today the only treatment available to halt the progression of FAP, even though LT is associated with several problems. Despite the urgent need to develop alternatives to LT, the detailed pathogenesis of FAP is still unknown; also, no model fully represents the relevant processes… CONTINUE READING
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