Generation of extracellular ATP in blood and its mediated inhibition of host weight loss in tumor-bearing mice.

@article{Rapaport1989GenerationOE,
  title={Generation of extracellular ATP in blood and its mediated inhibition of host weight loss in tumor-bearing mice.},
  author={Eliezer Rapaport and Josette Fontaine},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 23},
  pages={4261-6}
}
Intraperitoneal injections of adenosine 5'-monophosphate (AMP) or adenosine 5'-triphosphate (ATP), but not of adenosine, inorganic phosphate or pyrophosphate, were shown to inhibit tumor growth and host weight loss in tumor-bearing murine hosts. The inhibition of tumor growth and host weight loss did not exhibit a cause-effect relationship, though both were mediated through expansion of red blood cell (RBC) ATP pools which were promoted by administered adenine nucleotides. We then demonstrated… CONTINUE READING

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