Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells.

@article{Losada2019GenerationOE,
  title={Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells.},
  author={Alejandro Losada and Juan Jos{\'e} Berlanga and Jos{\'e} Manuel Molina-Guijarro and Antonio Jim{\'e}nez-Ruiz and Federico Gago and Pablo M. Avil{\'e}s and César de Haro and Juan Fernando Mart{\'i}nez-Leal},
  journal={Biochemical pharmacology},
  year={2019},
  pages={
          113744
        }
}
Plitidepsin (PLD, Aplidin®), a cyclic depsipeptide originally isolated from the marine tunicate Aplidium albicans, has been recently approved by Australian regulatory authorities for the treatment of multiple myeloma patients. Plitidepsin binds to eEF1A2 and induces oxidative stress, Rac1 activation and JNK1 phosphorylation, triggering a rapid apoptotic program in tumor cells. Since oxidative stress is one of the known sources of endoplasmic reticulum stress, we investigated whether PLD was… Expand
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