Generation of donor natural killer cells from CD34+ progenitor cells and subsequent infusion after HLA-mismatched allogeneic hematopoietic cell transplantation: a feasibility study

@article{Yoon2010GenerationOD,
  title={Generation of donor natural killer cells from CD34+ progenitor cells and subsequent infusion after HLA-mismatched allogeneic hematopoietic cell transplantation: a feasibility study},
  author={Suk Ran Yoon and Yuh Shan Lee and Sung Hyun Yang and Kang Hee Ahn and Je-H Lee and Ju-H Lee and Dae Yoon Kim and Young Ae Kang and Mijin Jeon and Miee Seol and Seong Gon Ryu and Jun Won Chung and Ilseung Choi and Kyung Hwa Lee},
  journal={Bone Marrow Transplantation},
  year={2010},
  volume={45},
  pages={1038-1046}
}
Post transplant infusion of donor-type natural killer (NK) cells has been shown to have an anti-leukemia-enhancing effect without evoking GVHD in murine hematopoietic cell transplantation (HCT) models. Here, we tested 14 patients (age, 23–65 years), 12 with acute leukemia and 2 with myelodysplastic syndrome, who underwent HLA-mismatched HCT and subsequently received donor NK cell infusions. Cell donors (age, 16–51 years), comprising seven siblings, five offspring, and two mothers of the… CONTINUE READING

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