Generation of diversity of the beta chain of the human T-lymphocyte receptor for antigen.

@article{Leiden1986GenerationOD,
  title={Generation of diversity of the beta chain of the human T-lymphocyte receptor for antigen.},
  author={Jeffrey M. Leiden and Jack Leonard Strominger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 12},
  pages={
          4456-60
        }
}
Human T-cell receptor beta-chain (Ti beta) genes are formed by the rearrangement of variable (V), diversity (D), and joining (J) gene segments. A comparison of the nucleotide and deduced amino acid sequences of the variable regions of six human Ti beta cDNAs reveals that they display a level of homology similar to that shared by human immunoglobulin heavy chain V genes. In contrast to immunoglobulin V regions, which contain three discrete regions of hypervariability, the Ti beta V regions… CONTINUE READING
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