Generation of distinct signaling modes via diversification of the Egfr ligand-processing cassette.


Egfr ligand processing in Drosophila involves trafficking of the ligand precursor by the chaperone Star from the endoplasmic reticulum (ER) to a secretory compartment, where the precursor is cleaved by the intramembrane protease Rhomboid. Some of the Drosophila Rhomboids also reside in the ER, where they attenuate signaling by premature cleavage of Star… (More)
DOI: 10.1242/dev.049858

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