Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M.

@article{Deacon2002GenerationOD,
  title={Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M.},
  author={Elizabeth M Deacon and Trevor R. Pettitt and Paul D. Webb and Timothy G. Cross and Hema Chahal and Michael J O Wakelam and Janet M. Lord},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 5},
  pages={983-9}
}
Protein kinase C (PKC) is a family of 11 isoenzymes that are differentially involved in the regulation of cell proliferation. PKC-betaII, a mitotic lamin kinase, has been shown previously to translocate to the nucleus at G(2)/M and this was coupled to the generation of nuclear diacylglycerol. However, it is not clear how isoenzyme selective translocation and nuclear targeting is achieved during cell cycle. To investigate further the role of nuclear diacylglycerol we measured PKC isoenzyme… CONTINUE READING

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