Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly

@inproceedings{Tojkander2015GenerationOC,
  title={Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly},
  author={Sari Tojkander and Gergana Gateva and Amjad Husain and Ramaswamy Krishnan and Pekka Lappalainen and Ewa K Paluch},
  booktitle={eLife},
  year={2015}
}
Adhesion and morphogenesis of many non-muscle cells are guided by contractile actomyosin bundles called ventral stress fibers. While it is well established that stress fibers are mechanosensitive structures, physical mechanisms by which they assemble, align, and mature have remained elusive. Here we show that arcs, which serve as precursors for ventral stress fibers, undergo lateral fusion during their centripetal flow to form thick actomyosin bundles that apply tension to focal adhesions at… CONTINUE READING

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