Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor cells

@article{Alder1999GenerationOC,
  title={Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor cells},
  author={Janet Alder and K. Jessica Lee and Thomas M. Jessell and Mary E Hatten},
  journal={Nature Neuroscience},
  year={1999},
  volume={2},
  pages={535-540}
}
Cerebellar granule neurons, the most abundant class of CNS neurons, have a critical role in cerebellar function. Granule neurons are generated at the dorsal border of the mesencephalon and metencephalon, the rhombic lip. In the mouse embryo, rhombic lip cells express a number of granule neuron markers, notably the bHLH transcription factor Math1. Dorsal midline cells adjacent to the rhombic lip express Bmp6, Bmp7 and Gdf7, three genes encoding peptide growth factors of the bone morphogenetic… CONTINUE READING
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