Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its applicability for donor leukocyte transfusions in marrow grafted CML patients

@article{Osman1999GenerationOB,
  title={Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its applicability for donor leukocyte transfusions in marrow grafted CML patients},
  author={Yasser Mohamed Osman and Masuhiro Takahashi and Zhiyin Zheng and Tadashi Koike and Ken Toba and Aichun Liu and Tatsuo Furukawa and Sadao Aoki and Yoshifusa Aizawa},
  journal={Leukemia},
  year={1999},
  volume={13},
  pages={166-174}
}
Dendritic cells (DC), the most potent ‘professional' antigen-presenting cells, hold promise for improving the immunotherapy of cancer. In this study, we investigated the ability of normal donor DC pulsed ex vivo with 12 mer bcr-abl (b3a2) peptide to generate b3a2-specific autologous or HLA-identical sibling donor's cytotoxic T-lymphocytes (CTL). DC that were grown from normal peripheral blood adherent cells or purified DC precursors in the presence of GM-CSF and IL-4, were pulsed with b3a2… CONTINUE READING
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