Generation of arachidonic acid and diacylglycerol second messengers from polyphosphoinositides in ischemic fetal brain.

@article{Kunievsky1992GenerationOA,
  title={Generation of arachidonic acid and diacylglycerol second messengers from polyphosphoinositides in ischemic fetal brain.},
  author={B. Kunievsky and Nicolas G Bazan and Ephraim Yavin},
  journal={Journal of neurochemistry},
  year={1992},
  volume={59 5},
  pages={
          1812-9
        }
}
Intracerebral administration of [3H]arachidonic acid ([3H]ArA) into 19-20-day-old rat embryos, resulted in a rapid incorporation of label into brain lipids. One hour after injection, 55.6 +/- 8.2, 18.0 +/- 3.4, and 13.7 +/- 1.3% of the total radioactivity was associated with phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine, respectively. Approximately 10% of radioactivity was found acylated in neutral lipids of which free ArA comprised only 1.5 +/- 0.2% of the total… CONTINUE READING

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