Generation of antiviral CD11ahigh T cells in CD4+ T cell-depleted mice and adult thymectomized mice after mouse hepatitis virus infection.


The mechanism of CD11ahighCD8+ T cell induction after mouse hepatitis virus infection, which has been suggested to play a key role in the elimination of infectious virus from the spleen in C57BL/6 mice, was studied. In CD4+ T cell-depleted mice, CD11ahighCD8+ T cells were induced in the spleen and spleen cells showed virus-specific cytotoxic T lymphocyte… (More)


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