Generation of anti-tumor response by JAWS II mouse dendritic cells transduced with murine interleukin 12 genes.

Abstract

Murine dendritic cells (DCs) of the established JAWS II cell line were transduced with a retroviral vector carrying murine interleukin 12 (IL-12) genes (JAWS II/IL-12 cells). The JAWS II/IL-12 cells produced approximately 9-18 ng IL-12 protein/ml/5 x 10(5) cells/48 h and displayed an increased CD80 and CD86 expression as well as major histocompatibility… (More)

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